Graphical Abstract
Stereochemically controlled cyclisation of 4-sulfanyl-1,3-diols leads to surprisingly stable 1,2-oxathianes in good yields.
|
| The stereochemically controlled synthesis of spirocyclic ethers and lactones with medium-sized (7-, 8-, and 12-membered) carbocyclic rings by phenylthio migration: 1-oxaspiro[4.n]alkanes and alkan-2-ones with N = 6, 7, and 11. Tetrahedron Letters, Volume 34, Issue 42, 15 October 1993, Pages 6783-6786 Kelly Chibale, Richard C. Hartley, Kevin P. Jenkins, Matthew Simons, Stuart Warren, Ian C. Richards
|
Graphical Abstract
Two new series of spirocyclic tetrahydrofurans, butan- and butenolides, and allylic sulphides can be made by stereospecific acid-catalysed rearrangement.
Graphical abstract
The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.